In order to encourage domestic manufacture and lessen India’s reliance on imported goods, the Make in India initiative imposed higher import levies. Using quarterly data from 2013-14 Q4 to 2025-26 Q3, this study examines the relationship between import tariffs, import dependence, and manufacturing growth in order to assess the efficacy of this strategy. Ordinary Least Squares (OLS) regression, trend analysis, and correlation analysis are all used in the analysis. Two regression models are estimated: one looks at the factors that influence import dependency, and the other evaluates how tariff policy affects the expansion of manufacturing. The findings show a statistically significant correlation between import dependence and import tariffs; nevertheless, increased tariffs by themselves have not significantly reduced reliance on foreign goods. Additionally, the results show that during the study period, tariff increases had no statistically significant impact on the growth of manufacturing. These findings imply that while tariff protection helps India’s import-substitution strategy, complementary policies like infrastructure development, investment promotion, technological advancement, and increased industrial competitiveness are necessary for sustainable industrial development. The paper presents empirical evidence on the efficiency of tariff-based trade policy in promoting India’s objective of economic self-reliance.